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Plasma cell depletion using proteasome inhibitions. A. Autoreactive plasma cells are thought to have increased rates of antibody synthesis, because self-antigens are present in vast amounts and are not eliminated like antigens from pathogens. B. Proteasome Inhibitors, like bortezomib, which selectively deplete plasma cells due to their high protein synthesis rates, may be a potential therapeutic to remove autoreactive plasma cells secreting anti-brain autoantibodies.
