Figure 3.
Tbr1 haploinsufficiency results in defects of intra- and inter-amygdalar axonal projections. (A) Wild-type mice. (B) Tbr1+∕− mice. (C) Tbr1+∕− mice with D-cycloserine or clioquinol injection. The interamygdalar projection via the posterior part of the anterior commissure is significantly impaired in Tbr1+∕− mice. Intraamygdalar connections between basolateral and central amygdalae are also noticeably reduced in Tbr1+∕− mice. Tbr1+∕− mice are characterized by autism-like behaviors. Increased neuronal activity in the amygdala using either D-cycloserine or clioquinol restores behavioral defects to normal levels, although axonal projection defects are not rescued.