Table 3.
TBR1 influences the expression (upregulation or downregulation) of genes associated with autism or dyslexia.
Gene symbol | Gene name | Molecular function | Tbr1−∕− vs. WT | Disease |
---|---|---|---|---|
Cd44 | CD44 molecule (Indian blood group) | Cell adhesion | Up | Autism |
Cdh8 | Cadherin 8, type 2 | Cell adhesion | Up | Autism |
Cntn6 | Contactin 6 | Cell adhesion | Up | Autism |
Gpc6 | Glypican 6 | Cell adhesion | Up | Autism |
Ntng1 | Netrin G1 | Cell adhesion | Up | Autism |
Kiaa0319 | Hypothetical protein D130043K22 | Cell adhesion | Up | Dyslexia |
Nefl | Neurofilament, light polypeptide | Cytoskeleton | Up | Autism |
Gpd2 | Glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | Enzyme | Up | Autism |
Drd1 | Dopamine receptor D1A | Neurotransmission | Down | Autism |
Gad1 | Glutamate decarboxylase 1 (brain, 67 kDa) | Neurotransmission | Up | Autism |
Grin2b | Glutamate receptor, ionotropic, N-methyl D-aspartate 2B | Neurotransmission | Down | Autism |
Baiap2 | BAI1-associated protein 2 | Signaling | Down | Autism |
Lasp1 | LIM and SH3 protein 1 | Signaling | Down | Autism |
Lypd6 | LY6/PLAUR domain containing 6 | Signaling | Down | Autism |
Ppp1r1b | Protein phosphatase 1, regulatory (inhibitor) subunit 1B | Signaling | Down | Autism |
Ptprk | Protein tyrosine phosphatase, receptor type, K | Signaling | Down | Autism |
Reln | Reelin | Signaling | Down | Autism |
Auts2 | Autism susceptibility candidate 2 | Transcription factor | Down | Autism |
Nfia | Nuclear factor I/A | Transcription factor | Down | Autism |
Nr4a2 | Nuclear receptor subfamily 4, group A, member 2 | Transcription factor | Down | Autism |
Sox5 | SRY (sex determining region Y)-box 5 | Transcription factor | Down | Autism |
Slc4a10 | Solute carrier family 4, sodium bicarbonate transporter, member 10 | Transporter | Up | Autism |
Stxbp6 | Syntaxin binding protein 6 (amisyn) | Vesicle trafficking | Up | Autism |
Sv2b | Synaptic vesicle glycoprotein 2B | Vesicle trafficking | Down | Autism |