Figure 2.
Brain state discriminability and relation to clinical symptoms. (A) Effective connectivity measures computed for task and resting-state data were subjected to classification analyses to determine, within each individual, the extent to which the 2 brain states could be discriminated. For both the arithmetic and social attention task, evoked and intrinsic brain states were discriminated with a high degree of accuracy in TD children, in contrast with results observed in children with ASD. (B) Children with ASD who were most severely affected on restricted and repetitive behaviors showed the greatest degree of similarity between causal connectivity measures in the arithmetic task and rest (n = 17; r = −0.51, P = 0.02), (C) and to some degree in the social attention task and rest (n= 15; r = −0.47, P = 0.07). As can be seen in B and C, task/rest discriminability scores were overall much higher for the arithmetic task than for the social attention task.