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. 2015 Aug 17;33(33):3880–3886. doi: 10.1200/JCO.2015.61.7779

Table 4.

Performance of the Combination of DAS and Pro-SFTPB in the Validation Set

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Measure Total Timing of Blood Draw
0-6 Months > 6-12 Months
Pro-SFTPB + DAS
    AUC 0.732 0.808 0.688
        95% CI 0.673 to 0.791 0.724 to 0.891 0.609 to 0.767
    Sensitivity at 95% specificity 0.222 0.350 0.176
    Specificity at 95% sensitivity 0.181 0.388 0.140
    P (v DAS) < .001 < .001 < .001
    P (v pro-SFTPB) < .001 < .001 .0634
DAS
    P < .001 < .001 .0409
    AUC 0.650 0.740 0.588
        95% CI 0.585 to 0.716 0.634 to 0.846 0.505 to 0.671
    Sensitivity at 95% specificity 0.120 0.275 0.059
    Specificity at 95% sensitivity 0.111 0.063 0.088
Pro-SFTPB
    P < .001 < .001 < .001
    AUC 0.699 0.741 0.675
        95% CI 0.639 to 0.760 0.650 to 0.831 0.595 to 0.755
    Sensitivity at 95% specificity 0.157 0.175 0.191
    Specificity at 95% sensitivity 0.194 0.363 0.169

Abbreviations: AUC, area under the curve; DAS, N1,N12-diacetylspermine; pro-SFTPB, pro-surfactant protein B.