. 2015 Dec 2;10:65. doi: 10.1186/s13024-015-0061-4

Table 3.

Logistic regression models^a predicting likelihood of clinical dementia per unit of term

Model terms	Model 1			Model 2			Model 3			Model 4
Model terms	Odds ratio	95 % CI	p-value	Odds ratio	95 % CI	p-value	Odds ratio	95 % CI	p-value	Odds ratio	95 % CI	p-value
AD pathology	3.15	1.80–5.73	<0.001	2.84	1.60–5.22	<0.001	3.16	1.81–5.75	<0.001	2.83	1.59–5.21	<0.001
Macroinfarcts	2.16	1.20–3.94	0.010	2.06	1.14–3.79	0.017	2.20	1.22–4.02	0.009	2.05	1.13–3.78	0.018
Microinfarcts	0.73	0.39–1.36	0.326	0.77	0.41–1.43	0.412	0.75	0.40–1.40	0.370	0.77	0.41–1.43	0.409
Arteriolosclerosis	1.30	0.95–1.78	0.098	1.34	0.98–1.84	0.068	1.32	0.97–1.82	0.078	1.33	0.98–1.84	0.071
Atherosclerosis	1.36	1.02–1.82	0.035	1.36	1.02–1.84	0.038	1.34	1.00–1.80	0.046	1.36	1.02–1.84	0.038
Lewy bodies	4.92	1.79–15.40	0.002	4.63	1.67–14.70	0.003	4.93	1.79–15.51	0.002	4.62	1.66–14.66	0.003
Hipp sclerosis	4.39	1.72–12.16	0.002	4.41	1.70–12.39	0.002	4.59	1.78–12.80	0.001	4.38	1.68–12.34	0.002
M18L^b				0.68	0.50–0.90	0.008				0.67	0.47–0.93	0.018
M18S^b							0.84	0.64–1.10	0.208	1.03	0.75–1.43	0.871

Abbreviations: AD Alzheimer’s disease, CI confidence interval Hipp, hippocampal, M18L/S Munc18-1 long/short splice variant

^aAll models were controlled for age, sex and education

^bStandardized M18L/S values (z-scores) were used