Table 1.
NF-κB and its regulators in the control of T-cell functions
| NF-κB & regulators |
Function in T cells | References |
|---|---|---|
| RelA | Th1, Th17, Treg differentiation | (Oh and Ghosh, 2013; Ruan and Chen, 2012) |
| RelB | Th1 differentiation | (Corn et al., 2005) |
| c-Rel | Th1, Th17, Treg differentiation | (Oh and Ghosh, 2013; Ruan and Chen, 2012) |
| p50 | Th2 differentiation | (Das et al., 2001) |
| p52 | Th9 differentiation | (Xiao et al., 2012) |
| Bcl-3 | Th1 plasticity and effector function | (Tang et al., 2014) |
| NIK | T-cell memory, Th17 effector function, Treg cell survival | (Murray, 2013; Rowe et al., 2013; Yu et al., 2014) |
| Ubc13 | Peripheral T-cell maintenance, Treg function and stability | (Chang et al., 2012; Yamamoto et al., 2006) |
| IKKβ | Treg function and stability | (Chang et al., 2012) |
| Tak1 | Survival of conventional T and Treg cells | (Chang et al., 2015; Wan et al., 2006) |
| CYLD | Controls NF-κB basal activity, maintains T-cell homeostasis | (Reiley et al., 2007) |
| A20 | Inhibits TCR-stimulated NF-κB activation, suppresses CD8 T-cell activation | (Giordano et al., 2014) |
| Peli1 | Promotes c-Rel degradation, inhibits T-cell activation | (Chang et al., 2011) |
| IκBαΔN | Inhibits NF-κB basal activity, impairs naïve T-cell survival | (Miller et al., 2014) |
| p100 Lym1 | Inhibits Th17 effector function, inhibits EAE induction | (Yu et al., 2014) |
IκBαΔN, a degradation-resistant IκBα mutant lacking its N-terminal region required for phosphorylation and degradation; p100 Lym1, a processing-deficient p100 mutant lacking its C-terminal phosphorylation site.