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A standard immunohistochemistry (IHC) panel for the three main clinical biomarkers ER, PR, and HER2 can approximate the four intrinsic breast cancer molecular subtypes.
| Breast cancer subtype | ER | PR | HER2 | Triple designation |
|---|---|---|---|---|
| Luminal A | + | ± | − | ER+PR±HER2− |
| Luminal B | + | ± | + | ER+PR±HER2+ |
| HER2+ | − | − | + | ER−PR−HER2+ |
| Basal-like | − | − | − | ER−PR−HER2− |
