Table 1.
Differences between right‐handed and left‐handed PD patients and between patients with contralateral (correct‐sided) and ipsilateral (wrong‐sided) dopaminergic deficit
| Variable | Right‐handed | Left‐handed | P‐valuea | Correct‐sided | Wrong‐sided | P‐valuea |
|---|---|---|---|---|---|---|
| n | 395 | 39 | – | 271 | 24 | – |
| Age (years) | 62.9 (9.81) | 63.0 (10.5) | 0.94 | 60.9 (10.0) | 65.1 (10.4) | 0.049 |
| Gender (m/f) | 251/144 | 25/14 | 0.95 | 164/107 | 16/8 | 0.67 |
| Predominant side of motor symptoms (right/left) | 153/114 | 8/20 | 0.005 | 151/120 | 10/14 | 0.21 |
| Predominant side of DAT binding defect (right/left) | 112/155 | 18/10 | 0.028 | 120/151 | 10/14 | 0.83 |
| Motor symptom severity (MDS‐UPDRS Part III score) | 20.2 (8.95) | 22.7 (10.0) | 0.10 | 18.4 (7.4) | 17.8 (8.0) | 0.75 |
| Mean DAT binding (SBR) | 0.833 (0.308) | 0.851 (0.325) | 0.74 | 0.866 (0.289) | 0.759 (0.268) | 0.082 |
| DAT binding asymmetry (%)b | 29.7 (17.5) | 29.7 (15.9) | 1.0 | 36.8 (13.9) | 22.3 (10.7) | <0.0001 |
| Motor symptom asymmetry (%)c | 66.0 (31.4) | 58.8 (26.2) | 0.17 | 76.6 (23.4) | 69.6 (24.0) | 0.17 |
| MDS‐UPDRS Part III tremor score | 5.64 (3.74) | 5.79 (3.23) | 0.80 | 5.35 (3.35) | 6.33 (4.05) | 0.18 |
| MDS‐UPDRS Part III without tremord | 14.6 (8.08) | 16.9 (9.12) | 0.09 | 13.0 (6.84) | 11.5 (6.32) | 0.30 |
| PD motor subtype (TD/PIGD/intermediate) | 335/36/24 | 34/2/3 | 0.67 | 230/21/20 | 21/2/1 | 0.84 |
| Tremor asymmetry index | 0.066 (0.779) | −0.067 (0.774) | 0.31 | 0.030 (0.837) | 0.035 (0.748) | 0.88 |
| Bradykinesia‐rigidity asymmetry index | 0.096 (0.747) | −0.135 (0.660) | 0.064 | 0.100 (0.808) | −0.192 (0.784) | 0.090 |
| Symptoms on correct/wrong body side | 245/22 | 26/2 | 1.0 | – | – | – |
| Handedness (r/l) | – | – | – | 245/26 | 22/2 | 1.0 |
Two‐hundred and ninety‐five PD patients with clearly lateralized tracer uptake and clearly lateralized motor symptoms were included in the analysis of corrected‐sided and wrong‐sided symptoms. Values are means (SD) or n. PD, Parkinson's disease; DAT, dopamine transporter; SBR, specific binding ratio; TD, tremor‐dominant subtype; PIGD, postural instability and gait disorder subtype.
Independent samples t‐test or chi‐square test.
([higher − lower putamen SBR]/higher putamen SBR) × 100.
([worse − better side MDS‐UPDRS]/better side MDS‐UPDRS) × 100.
MDS‐UPDRS Part III total score − MDS‐UPDRS Part III tremor score (11 items).