Table 2.
Metabolomics analysis of Al2O3 NPs exposed HBE cell lysates
| Peak | Metabolic pathway | HMDB | Regulation |
|---|---|---|---|
| 3-Phenylbutyric Acid | Taurine and Hypotaurine Metabolism | HMDB01955 | down |
| Melatonin | Tryptophan Metabolism | HMDB01389 | down |
| cis-Aconitic acid | Citric Acid Cycle | HMDB00072 | down |
| 3-Methylhistidine | Histidine Metabolism | HMDB00479 | down |
| Acetyl-L-carnitine | Beta Oxidation of Very Long Chain Fatty Acids | HMDB00201 | down |
| 4-Methoxyphenylacetic acid | Tyrosine Metabolism | HMDB02072 | down |
| N-Acetyl-L-methionine | Betaine Metabolism | HMDB11745 | down |
| N-Formyl-L-methionine | Betaine Metabolism | HMDB01015 | down |
| Pyridoxal 5′-phosphate | Vitamin B6 Metabolism | HMDB01491 | down |
| L-Serine | Homocysteine Degradation | HMDB00187 | up |
| Adenine | Phytanic Acid Peroxisomal Oxidation | HMDB00034 | up |
| Succinic acid | Aspartate Metabolism | HMDB00254 | up |
| D-Glutamic acid | Glutamate Metabolism | HMDB03339 | up |
| Thymine | Pyrimidine Metabolism | HMDB00262 | up |
| Ethylmalonic acid | Mefanamic Acid Pathway | HMDB00622 | up |
| Ureidopropionic acid | Beta-Alanine Metabolism | HMDB00026 | up |
| (-)Matairesinol | Phenylacetate Metabolism | HMDB35698 | up |
| Taurocholic Acid | Bile Acid Biosynthesis | HMDB00036 | up |
| Docosahexaenoic acid | Mefanamic Acid Pathway | HMDB02183 | up |
| Pyridoxine | Vitamin B6 Metabolism | HMDB00239 | up |