Skip to main content
. Author manuscript; available in PMC: 2017 Jan 6.
Published in final edited form as: Neuron. 2015 Dec 10;89(1):147–162. doi: 10.1016/j.neuron.2015.11.023

Figure 8. InsG3680 Mice Show More Profound Repetitive Self-Grooming, whereas R1117X Mice Display Allogrooming and Dominance-like Behavior.

Figure 8

(A) Representative pictures from an adult wild-type and an InsG3680+/+ mouse that developed a lesion in the head/neck area.

(B and C) Time spent on grooming during 2 hr videotaping of indicated genotypes as normalized to their wild-type littermates. In the InsG3680 cohort, n = 9 mice for wild-type; n = 9 mice for InsG3680+/−; n = 10 mice from InsG3680+/+ group. In the R1117X cohort, n = 9 mice for wild-type, n = 9 mice for R1117X+/−; n = 9 mice for R1117X+/+. Data are presented as mean ± SEM. *p < 0.05; Kruskal-Wallis test with Dunn’s post hoc comparison.

(D) Representative pictures of an R1117X+/− mouse with intact facial hair and a wild-type mouse shaved by its cage mate as an indication for allogrooming behavior.

(E) Diagram of tube test task between two unfamiliar mice with different genotypes.

(F and G) Percentage of wins in test pairs between indicated genotypes, 11/18 (61%) of R1117X+/− versus WT; 16/18 (89%) of R1117X+/+ versus WT; 6/14 (43%) of InsG3680+/− versus WT; 8/11 (73%) of InsG3680+/+ versus WT. Note that both R1117X+/− and R1117X+/+ mice perform significantly above chance level. One-sample chi-square test was used to determine the significant difference. “*” indicates significantly different from an expected chance (50:50 win-lose outcome).