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IC50 values of succinate, fumarate, citrate, and (R)- and (S)-2-hydroxyglutarate for Tets 1 and 2
The values are mean ± S.D. of 3 to 4 independent assays.
| Enzyme | Unit | Citrate | Succinate | Fumarate | R-2HGa | S-2HGa |
|---|---|---|---|---|---|---|
| Tet1 | μm | >5000 | 540 ± 100 | 390 ± 160 | 4000a | 1000a |
| Tet2 | μm | >5000 | 570 ± 190 | 400 ± 70 | 5000a | 1600a |
a Ref. 25.
