Table 2.
DTI results
| A: Main effects | Anatomical location | k | Pea k T |
Cluster level P value |
|---|---|---|---|---|
| P-Tau181 | ||||
| Fractional Anisotropy | thalamus (L,R) | 567 | 5.07 | 0.015 |
| Mean diffusivity | inferior frontal gyrus (L) | 211 | 4.00 | 0.031 |
| NFL | ||||
| Mean Diffusivity | cuneus (L) | 689 5 |
5.51 | <0.001* |
| superior parietal lobule (R) | 608 5 |
4.80 | <0.001* | |
| middle frontal gyrus (R) | 252 1 |
4.17 | <0.001* | |
| pre-central gyrus (L) | 989 | 3.96 | 0.025 | |
| hippocampus (R) | 987 | 4.76 | 0.029 | |
| T-Tau | ||||
| Fractional Anisotropy | thalamus (L,R) | 433 | 4.89 | 0.021 |
| Mean Diffusivity | precuneus (L,R) | 144 94 |
5.54 | <0.001* |
| cuneus (L) | 798 | 4.34 | 0.008 | |
| fusiform (R) | 437 | 4.31 | 0.018 | |
| Inferior orbitofrontal (L) | 222 | 4.43 | 0.027 |
| B: Inflammation × Alzheimer's marker interactions |
Anatomical location | k | Pea k T |
Cluster level P value |
|---|---|---|---|---|
| Aβ42x MCP1 | ||||
| Mean Diffusivity | inferior frontal gyrus (R) | 772 | 4.52 | 0.002 |
| inferior temporal gyrus (R) | 329 | 3.46 | 0.027 | |
| fusiform (L) | 357 | 4.20 | 0.029 | |
| Inferior frontal gyrus (L) | 139 | 3.71 | 0.041 | |
| P-Tau181 × YKL-40 | ||||
| Mean Diffusivity | precuneus (L) | 617 | 3.46 | 0.022 |
| P-Tau181 × MCP-1 | ||||
| Fractional Anisotropy | post central gyrus wm (R) | 671 | 4.94 | 0.0018 |
| anterior corona radiata (R) | 395 | 4.37 | 0.013 | |
| anterior internal capsule (L) | 557 | 3.61 | 0.037 | |
| Mean Diffusivity | precuneus (L) | 520 | 3.92 | 0.034 |
| C: Interactions with neural injury |
Anatomical location | k | Pea k T |
Cluster level Pvalue |
|---|---|---|---|---|
| P-Tau181 × NFL | ||||
| Mean Diffusivity | precuneus (R) | 837 | 3.93 | 0.005 |
| YKL-40 × NFL | ||||
| Fractional Anisotropy | internal/external capsule (R) | 777 | 3.59 | 0.028 |
| Mean Diffusivity | angular gyrus (R) | 1353 | 6.77 | <0.001* |
| YKL-40 × T-Tau | ||||
| Fractional Anisotropy | internal/external capsule*, cerebral peduncle (L) |
103 5 |
4.16 | 0.008 |
| cerebral peduncle*, internal/external capsule (R) |
688 | 3.79 | 0.025 | |
| Mean Diffusivity | cerebellum (L) | 256 7 |
4.06 | 0.009 |
| superior frontal gyrus (L) | 113 3 |
3.60 | 0.022 | |
| P-Tau181 × T-Tau | ||||
| Mean Diffusivity | cuneus (L,R) | 757 | 4.23 | 0.012 |
R: right; L: left; MCP-1: monocyte chemoattractant protein; Aβ42: 42 residue amyloid beta peptide; T-Tau: Total tau; P-Tau: phosphorylated tau; NFL: neurofilament light chain protein; WM: white matter;
*
cluster peak location,
*
survives Bonferroni correction (α=0.05/36 contrasts, corrected α=0.0014)