Table 3.
Quantitative data from LC-MS-MS analysis
| pg/g tissue | Q1 | Q3 | AD | Control | p value |
|---|---|---|---|---|---|
| AA Bioactive Metabolome | |||||
| LXA4 | 351 | 115 | 934.1 ± 990.8 | 359.6 ± 188.5 | NS |
| LXB4 | 351 | 221 | 1369.0 ± 1024.7 | 3074.6 ± 2364.8 | NS |
| 5,15-diHETE | 335 | 115 | 3730.1± 4826.5 | 5437.6 ± 2171.1 | NS |
| LTB4 | 335 | 195 | 520.2 ± 453.0 | 782.0 ± 585.3 | NS |
| 20-OH-LTB4 | 351 | 195 | 155.1 ± 287.7 | 117.0 ± 220.4 | NS |
| PGD2 | 351 | 223 | 2609.7 ± 2304.8 | 476.5 ± 822.7 | 0.011 |
| PGE2 | 351 | 189 | 3718.7 ± 3308.3 | 1666.2 ± 2182.2 | NS |
| PGF2α | 353 | 193 | 1351.4 ± 1355.7 | 13738.3 ± 29679.1 | NS |
| TxB2 | 369 | 169 | 3581.5 ± 2597.2 | 2011.1 ± 2967.6 | NS |
| EPA Bioactive Metabolome | |||||
| RvE1 | 349 | 161 | 1174.3 ± 1469.9 | 6.1 ± 11.3 | NS |
| RvE2 | 333 | 115 | 64.0 ± 99.2 | 15.3 ± 26.2 | NS |
| DHA Bioactive Metabolome | |||||
| RvD1 | 375 | 215 | 80.7 ± 137.0 | 10.4 ± 27.5 | NS |
| RvD2 | 375 | 175 | 57.1 ± 95.1 | 11.8 ±20.3 | NS |
| RvD5 | 359 | 199 | 223 ± 150.6 | 433.6 ± 177.1 | 0.038 |
| MaR1 | 359 | 221 | * | 578.1 ± 426.9 | 0.026 |
| PD1 | 359 | 153 | 4.7 ± 12.5 | 3946.2 ± 3264.3 | 0.038 |
5,15-diHETE = 5, 15- dihydroxy- 6E, 8Z, 10Z, 13E- eicosatetraenoic acid; 20-OH-LTB4 = 20-Hydroxy-LTB4; LTB4 = leukotriene B4; LXA4 = lipoxin A4; LXB4 = lipoxin B4; PD1 = protectin D1; PGD2 = prostaglandin D2; PGE2 = prostaglandin E2; PGF2α = prostaglandin E2α; RvD1 = resolvin D1; RvD2 = resolvin D2; RvD5 = resolvin D5; RvE1 = resolvin E1; RvE2 = resolvin E2; MaR1 = maresin 1; TxB2 = thromboxane B2. Data are expressed as mean ± SD.
*
not detectable. NS = not significant.