Table 1.
Summary of main studies linking GBA and PD.
| Links between mutant GBA and PD | References |
|---|---|
| Subset of GD patients develop parkinsonism | Bembi et al. (2003), Neudorfer et al. (1996), Tayebi et al. (2001) |
| Genetic multi-centre study reporting statistically significant association between GBA mutations and PD | Sidransky et al. (2009) |
| Lewy bodies similar in PD brains with and without GBA mutations | Neumann et al. (2009), Parkkinen et al. (2011) |
| Accumulation and impaired turnover of α-synuclein in animal and cell models of GCase deficiency | Cullen et al. (2011), Fishbein et al. (2014), Manning-Boğ et al. (2009), Mazzulli et al. (2011), Osellame et al. (2013), Sardi et al. (2011), Schöndorf et al. (2014) |
| GCase activity decreased in sporadic PD | Gegg et al. (2012), Murphy et al. (2014) |
| α-synuclein affects GCase function | Gegg et al. (2012), Mazzulli et al. (2011), Sardi et al. (2013), Yap et al. (2011) |