Fig. 4.
VIVIT blocks the activation of the MyHC-slow but not of the MyHC-2B promoter in adult soleus muscle. (A) MyHC-slow promoter activity is inhibited in soleus muscle by cotransfection with VIVIT-GFP. (B) MyHC-2B promoter activity is significantly higher in the fast EDL than in the slow soleus muscle and is not affected by VIVIT-GFP. Luciferase activity is expressed as the percentage of that measured in soleus muscles injected with GFP alone. Data are mean ± SEM (n = 4). *, Significant difference from control soleus group (P < 0.05).