Table 1. FAAH activities in tissues from FAAH+/-, FAAH-/-, and FAAH-NS mice as measured by the hydrolysis of the FAAH substrate OEA (pmol/min per mg).
Brain | Spinal cord | Testis | Liver | Kidney | Spleen | |
---|---|---|---|---|---|---|
FAAH+/- | 133 ± 20 | 72 ± 13 | 30 ± 8 | 384 ± 69 | 36 ± 5 | 12 ± 3 |
FAAH-/- | 2 ± 1** | 2 ± 1** | 0.4 ± 0.1†† | 4 ± 0.4†† | 0.6 ± 0.1†† | 0.2 ± 0.1†† |
FAAH-NS | 326 ± 25 | 188 ± 32 | 0.4 ± 0.1†† | 4 ± 0.4†† | 0.5 ± 0.1†† | 0.1 ± 0.1†† |
, P < 0.01 for FAAH-/- mice vs. FAAH+/- mice or FAAH-NS mice
, P < 0.01 for FAAH-/- mice or FAAH-NS mice vs. FAAH+/- mice. Data are reported as means ± SE. n = 3 mice per group