Fig.2.
Transmission electron microscopic analysis of axonal spheroids in the medial forebrain bundle in the hLRRK2(R1441G) BAC transgenic mice revealed the presence of giant axonal spheroids containing large numbers of autophagic vacuoles. In A, a thinly myelinated axon (arrowheads) with well-organized cytoskeletal elements leads into a large spheroid that lacks myelin, contains disorganized cytoskeletal structures and is packed with autophagic vacuoles. The region in the white box is shown at higher magnification in B. Numerous vacuoles with double membranes, characteristic of autophagic vacuoles (AV), are observed. Interspersed among them are numerous multilamellar bodies (MLB).