Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1981 Apr;34(4):439–442. doi: 10.1136/jcp.34.4.439

Resistance to trimethoprim in 1978-79 compared with 1973-75.

J M Hamilton-Miller, A Gooding, W Brumfitt
PMCID: PMC493310  PMID: 7016927

Abstract

The incidence of resistance to trimethoprim among urinary isolates between October 1978 and November 1979 was 11.5%, more than double the figure found April 1973 and October 1975. Of the resistant strains, 60% had a minimum inhibitory concentration in excess of 1 mg/ml. Escherichia coli and Proteus mirabilis showed the greatest increase in resistance since the previous study. Rather wide fluctuations occurred in the incidence of resistance for various species when the figures were analysed over two-month periods, hence studies of short duration must be interpreted with caution. There are not yet enough data from this or other studies for the cause of the increased incidence of resistance to trimethoprim to be determined.

Full text

PDF
439

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acar J. F., Goldstein F. W., Gerbaud G. R., Chabbert Y. A. Plasmides de résistance au triméthoprime: transférabilité et groupes d'incompatibilité. Ann Microbiol (Paris) 1977 Jan;128A(1):41–47. [PubMed] [Google Scholar]
  2. Amyes S. G., Emmerson A. M., Smith J. T. R-factor mediated trimethoprim resistance: result of two three-month clinical surveys. J Clin Pathol. 1978 Sep;31(9):850–854. doi: 10.1136/jcp.31.9.850. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brumfitt W., Faiers M. C., Pursell R. E., Reeves D. S., Turnbull A. R. Bacteriological, pharmacological and clinical studies with trimethoprim-sulphonamide combinations with particular reference to the treatment of urinary infections. Postgrad Med J. 1969 Nov;45(Suppl):56–61. [PubMed] [Google Scholar]
  4. Brumfitt W., Hamilton-Miller J. M., Gooding A. Resistance to trimethoprim. Lancet. 1980 Jun 28;1(8183):1409–1410. [PubMed] [Google Scholar]
  5. Crichton P. B., Old D. C. Biotyping of Escherichia coli. J Med Microbiol. 1979 Nov;12(4):473–486. doi: 10.1099/00222615-12-4-473. [DOI] [PubMed] [Google Scholar]
  6. Grey D., Hamilton-Miller J. M., Brumfitt W. Incidence and mechanisms of resistance to trimethoprim in clinically isolated gram-negative bacteria. Chemotherapy. 1979;25(3):147–156. doi: 10.1159/000237834. [DOI] [PubMed] [Google Scholar]
  7. Grey D., Hamilton-Miller J. M. Trimethoprim-resistant bacteria: cross-resistance patterns. Microbios. 1977;19(75):45–54. [PubMed] [Google Scholar]
  8. Grüneberg R. N., Bendall M. J. Hospital outbreak of trimethoprim resistance in pathogenic coliform bacteria. Br Med J. 1979 Jul 7;2(6181):7–9. doi: 10.1136/bmj.2.6181.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Grüneberg R. N. Susceptibility of urinary pathogens to various antimicrobial substances: a four-year study. J Clin Pathol. 1976 Apr;29(4):292–295. doi: 10.1136/jcp.29.4.292. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hamilton-Miller J. M. Mechanisms and distribution of bacterial resistance to diaminopyrimidines and sulphonamides. J Antimicrob Chemother. 1979 Nov;5(B):61–73. doi: 10.1093/jac/5.supplement_b.61. [DOI] [PubMed] [Google Scholar]
  11. Huovinen P., Toivanen P. Trimethoprim resistance in Finland after five years' use of plain trimethoprim. Br Med J. 1980 Jan 12;280(6207):72–74. doi: 10.1136/bmj.280.6207.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jobanputra R. S., Datta N. Trimethoprim R factors in enterobacteria from clinical specimens. J Med Microbiol. 1974 May;7(2):169–177. doi: 10.1099/00222615-7-2-169. [DOI] [PubMed] [Google Scholar]
  13. Kasanen A., Anttila M., Elfving R., Kahela P., Saarimaa H., Sundquist H., Tikkanen R., Toivanen P. Trimethoprim. Pharmacology, antimicrobial activity and clinical use in urinary tract infections. Ann Clin Res. 1978;10 (Suppl 22):1–39. [PubMed] [Google Scholar]
  14. Lacey R. W., Lord V. L., Gunasekera H. K., Leiberman P. J., Luxton D. E. Comparison of trimethoprim alone with trimethoprim sulphamethoxazole in the treatment of respiratory and urinary infections with particular reference to selection of trimethoprim resistance. Lancet. 1980 Jun 14;1(8181):1270–1273. doi: 10.1016/s0140-6736(80)91732-8. [DOI] [PubMed] [Google Scholar]
  15. McAllister T. A., Alexander J. G., Dulake C., Percival A., Boyce J. M., Wormald P. J. Multicentric study of sensitivities of urinary tract pathogens. Postgrad Med J. 1971 Sep;47(Suppl):7–14. [PubMed] [Google Scholar]
  16. Romero E., Perduca M. Compatibility groups of R-factors for trimethoprim resistance isolated in Italy. J Antimicrob Chemother. 1977 Nov;3 (Suppl 100):35–38. doi: 10.1093/jac/3.suppl_c.35. [DOI] [PubMed] [Google Scholar]
  17. Towner K. J., Pearson N. J., Pinn P. A., O'Grady F. Increasing importance of plasmid-mediated trimethoprim resistance in enterobacteria: two six-month clinical surveys. Br Med J. 1980 Feb 23;280(6213):517–519. doi: 10.1136/bmj.280.6213.517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Trimethoprim--resistant coliforms. Lancet. 1977 Oct 29;2(8044):926–926. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES