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. Author manuscript; available in PMC: 2016 Jul 7.
Published in final edited form as: Results Probl Cell Differ. 2012;54:119–156. doi: 10.1007/978-3-642-21649-7_7

Table 1.

Genes identified to genetically interact with dFMRP

Gene Function Tissue interaction identified mRNA bound by dFMRP mRNA levels in dfmr1 nulls protein levels in dfmr1 nulls Reference
trailerhitch mRNA processing embryo yes upregulated downregulated Monzo et al. 2006
caprin mRNA translation embryo ND ND ND Papouolas et al. 2010
CCT3 chaperone complex embryo yes ND postranslationally modified Monzo et al. 2010
CCT4 chaperone complex embryo yes ND downregulated Monzo et al. 2010
CCT7 chaperone complex embryo yes ND upregulated Monzo et al. 2010
orb1 mRNA translation ovary ND ND upregulated Costa et al. 2005
cbl ubiquitin ligase activity ovary ND upregulated unaffected Epstein et al. 2009
bantam miRNA miRNA ovary yes unaffected - Yang et al. 2009
sticky citron kinase eye ND ND ND Bauer et al. 2010
orb2 mRNA binding eye ND ND ND Cziko et al. 2009
futsch/MAP1B microtubule binding larval NMJ yes ND upregulated Zhang et al. 2001
dmGluRA G-protein coupled receptor larval NMJ ND ND upregulated Pan et al. 2007, Repicky and Broadie 2009
lgl cytoskeletal binding larval NMJ/eye ND ND ND Zarnescu et al. 2005
aPKC protein kinase larval NMJ ND ND ND Zarnescu et al. 2005
argonaut 1 miRNA processing larval NMJ/eye ND ND ND Jin et al. 2004
argonaut 2 miRNA processing larval NMJ ND ND ND Pepper et al. 2009
spastin microtubule severing larval NMJ/eye ND ND unaffected Yao et al. 2010
Rac1 GTPase activity, actin organization DA neurons yes ND ND Lee et al. 2003
pickpocket sodium ion channel sensory neurons yes upregulated ND Xu et al. 2004
chickadee/profilin actin binding lateral clock circuit neurons yes upregulated upregulated Reeve et al. 2005, Tessier and Broadie 2008
Lark mRNA binding,actin organization clock circuit/eye ND ND unaffected Sofola et al. 2008
staufen mRNA translation adult brain ND ND ND Bolduc et al. 2008
cheerio/filimin A actin binding adult brain ND ND Reduced after spaced training Bolduc et al. 2010

ND: Not Determined