Table 3.
Hazard ratios (95% confidence interval [CI]) associated with 1 SD increase in clusterin plasma levels stratified by age
| Age | Cases/N | Model 1 |
Model 2 |
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |||
| All-cause dementia∗ | 60–69 | 16/937 | 0.53 (0.32–0.88) | .013 | 0.41 (0.22–0.76) | .005 |
| 70–79 | 52/555 | 1.05 (0.78–1.42) | .730 | 1.10 (0.82–1.48) | .539 | |
| 80–89 | 8/40 | 6.25 (1.64–23.89) | .007 | 55.5 (2.73–1130.87) | .009 | |
| Alzheimer's disease∗ | 60–69 | 12/937 | 0.59 (0.33–1.07) | .080 | 0.48 (0.24–0.96) | .038 |
| 70–79 | 39/555 | 1.03 (0.73–1.45) | .883 | 1.11 (0.79–1.57) | .548 | |
| 80–89 | 7/40 | 5.19 (1.45–18.62) | .011 | — | — | |
| Stroke | <80 | 102/3156 | 0.78 (0.63–0.97) | .029 | 0.75 (0.60–0.95) | .017 |
| ≥80 | 5/50 | 1.73 (0.75–3.96) | .197 | 1.22 (0.48–3.06) | .678 | |
NOTE. Values in bold indicate P ≤.05.
NOTE. Model 1: Adjusted for age and sex.
NOTE. Model 2: Adjusted in addition for hypertension, smoking, prevalent diabetes, body mass index, and APOE ε4 genotype status.
∗
Models are also adjusted for prevalent stroke.