Table 2. CA1 Schaffer collateral plasticity.
| CA1 | ||||||||
|---|---|---|---|---|---|---|---|---|
| basal synaptic transmission | short-term plasticity | long-term plasticity | ||||||
| I/O | PPR | PTP | LTP | |||||
|
| ||||||||
| Pro-ON | - | n = 13 | - | n = 13 | ↓ | 158 ± 12%, n = 8 | ↓ | 92 ± 6%, n = 8 p < 0.0001 |
| Pro-ON/OFF | - | n = 7 | - | n = 8 | ↓ | 158 ± 13%, n = 13 | - | 130 ± 13%, n = 10 |
| Anti-ON | - | n = 10 | - | n = 10 | ↑ | 198 ± 16%, n = 6 | ↑ | 149 ± 18%, n = 6 |
| Anti-ON/OFF | - | n = 7 | - | n = 10 | ↑ | 198 ± 21%, n = 10 | - | 114 ± 13%, n = 10 |
| Control | - | n = 10 | - | n = 9 | - | 180 ± 19%, n = 9 | - | 121 ± 13%, n = 10 |
Pro-ON: pro-aggregant 16 months ON; Pro-ON/OFF: pro-aggregant 12 months ON + 4 months OFF; Anti-ON: anti-aggregant 16 months ON; Anti-ON/OFF: anti-aggregant 12 months ON + 4 months OFF; Control (16 months); I/O: input/output curve; PPR: paired pulse ratio; PTP: post tetanic potentiation; LTP: long term potentiation; ↓: decrease; ↑: increase; -: no change. Data represents mean ± SEM. Statistical comparison of I/O, PTP and LTP by repeated measure ANOVA; comparison of PPR by Student´s t-test.