Table I.
Examples of pharmacogenomic tests with associated CPT codes for identification and documentation.
| CPT Code | Test | Description of Test |
|---|---|---|
| 81225 | CYP2C19 genotyping | Detects genetic variants of CYP2C19 associated with variable drug metabolism |
| 81226 | CYP2D6 genotyping | Detects genetic variants of CYP2D6 associated with variable drug metabolism |
| 81227 | CYP2C9 genotyping | Detects genetic variants of CYP2C9 associated with variable drug metabolism |
| 81355 | VKORC1 testing | Detects genetic variants of VKORC1 associated with warfarin therapy |
| 81350 | UGT1A1 genotyping | Detects genetic variants of UGT1A1 associated with irinotecan toxicity |
| 84431 | 11-dehydro thromboxane B2 | Measures 11-dehydro thromboxane B2 in urine to determine aspirin resistance |
| 81381 | HLA B*57:01 | Detects the HLA B*57:01 allele associated with abacavir toxicity |
| 82955 | G6PD quantitative | Measures glucose-6-phosphate dehydrogenase activity |
| 81210 | BRAF mutation testing | Detects mutations in BRAF associated with BRAF inhibitor therapy |
| 81275 | KRAS mutation testing | Detects mutations in KRAS associated with KRAS inhibitor therapy |
| 88360 | HER2 expression | Detects the expression of HER2 to guide therapy with HER2 inhibitors |
| 81235 | EGFR mutation testing | Detects mutations in EGFR associated with EGFR inhibitor therapy |
| 81220 | CFTR profile | Detects mutations in CFTR, which is necessary prior to therapy with ivacaftor |
| 87999 | HIV-1 tropism testing | Determines HIV tropism for chemokine receptor 5 [CCR5], and/or chemokine receptor 4 [CXCR4] to guide therapy with receptor antagonists |
| 81287 | MGMT gene methylation | Determines MGMT methylation status to guide therapy with alkylating agents |
Note: some tests may be components of multi-test panels offered by various companies.