Fig. S3.
SPN burst activity analyzed with four different methods in patients with PD, ID, and ET and normal and parkinsonian NHPs. Proportion of bursty SPNs and burst rate per bursty SPN across patient and NHP groups were analyzed with (A) surprise method, (B) RGS method, (C) RS method, and (D) ISIN method. All four methods show similar higher proportion of bursty SPNs in PD and no burst detection in SPNs of patients with ET and the normal animal. Burst rate was lower with the RGS and ISIN methods. Significant differences in the burst rate across patient groups were found consistently with all four methods. *P < 0.001 versus ID, ET (ANOVA followed by Bonferroni post hoc test) or versus N (normal) NHP (unpaired t test). Error bars represent SEM.