Table 3.
Alzheimer’s disease-type dementia survival probability by the IWG-1, IWG-2 and NIA-AA criteria
| 3-year progression rate to Alzheimer’s disease-type dementia* | Hazard ratio** (95% CI) | P-value | |
|---|---|---|---|
| IWG-1 | |||
| No prodromal Alzheimer’s disease | 21% | Reference | |
| Prodromal Alzheimer’s disease | 50% | 3.0 (2.4–3.7) | <0.0001 |
| IWG-2 | |||
| No prodromal Alzheimer’s disease | 22% | Reference | |
| Prodromal Alzheimer’s disease | 61% | 4.0 (3.0–5.2) | <0.0001 |
| NIA-AA | |||
| Low Alzheimer’s disease likelihood group | 5% | Reference | |
| High Alzheimer’s disease likelihood group | 59% | 14.4 (5.9–35.2) | <0.0001 |
| Conflicting IAP group | 22% | 4.6 (1.6–13.2) | 0.0050 |
| Conflicting SNAP group | 24% | 4.7 (1.8–11.9) | 0.0011 |
| Intermediate Alzheimer’s disease likelihood group | 49% | 10.2 (4.1–25.2) | <0.0001 |
| Uninformative/inconclusive group | 21% | 3.5 (1.4–8.8) | 0.0079 |
*Estimated 3-year progression (cumulative incidence) rate to Alzheimer’s disease-type dementia, **Hazard ratios (95% CI) for progression to Alzheimer’s disease-type dementia calculated using Cox regression analyses and corrected for baseline age, gender, education and centre.