Figure 1.
Impaired recognition memory of pre-juvenile dual-hit GE mice. (A) (i) Photograph of the arena used for testing novel object and OLR. The computer generated track of the mouse pup (yellow) is displayed together with zones (red, blue) created around the objects. (ii) Photograph of the objects with different textures, colors, shapes, and sizes that were used for NOR in pre-juvenile mouse pups. Scale bar: 2 cm. (B) Schematic diagrams of the protocol for (i) NOR, (ii) OLR, and (iii) RR tasks. (C) (i) Bar diagram illustrating the relative interaction time spent by control (n = 18, black) and dual-hit GE (n = 14, magenta) mice with the objects during the NOR test trial. The dotted line indicates chance level. (ii) Bar diagram illustrating the mean duration of a visit at the objects for control (black) and dual-hit GE (magenta) mice during the NOR test trial. (D) Same as (C) (i) for control (n = 18, black) and dual-hit GE (n = 15, magenta) mice in the OLR test trial. (E) Same as (C) (i) for control (n = 16, black) and dual-hit GE (n = 14, magenta) mice in the RR test trial. In (C–E) gray circles correspond to individual values. Data displayed as mean ± s.e.m.