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. 2016 Nov 14;213(12):2539–2552. doi: 10.1084/jem.20160437

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© 2016 Hong et al.

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Figure 3. — Recombinant human IFNλ4 shows similar antiviral activity to IFNλ3. (A) Renilla luciferase reporter activity measuring HCV replication in Huh7 cells infected with Renilla luciferase-tagged HCV and treated with rhIFNλ3 and rhIFNλ4. (B) WNV RNA load upon treatment of infected Huh7 cells with equal doses of rhIFNλ3 and rhIFNλ4. (C) Correlation of ISG induction in WNV-infected Huh7 cells from B stimulated with 100 ng/ml rhIFNλ3 and rhIFNλ4, based on a TaqMan qPCR array of 37 ISGs. A and B are representative of three independently performed experiments; data in C is from one array. Statistical analysis was performed using one-way ANOVA with multiple comparisons against unstimulated cells (A and B). ***, P < 0.001.