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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Alzheimers Dement. 2016 Aug 29;13(1):8–19. doi: 10.1016/j.jalz.2016.07.005

Figure 5.

Figure 5

Proportional hypothetical treatment effects yield different absolute changes depending on EYO. The red line represents the natural (i.e. placebo) rate of cognitive decline across EYO. The colored lines illustrate different levels of slowing disease progression based on drug effect across EYO.