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. Author manuscript; available in PMC: 2018 Jan 25.
Published in final edited form as: Cell Syst. 2016 Dec 15;4(1):60–72.e4. doi: 10.1016/j.cels.2016.11.006

Fig. 6. AD GWAS candidates are over-represented in protein and RNA networks associated glial cell types.

Fig. 6

(A) AD GWAS candidate genes (darkslateblue) in the BLSA network were found significantly over-represented in oligodendrocyte module (B-M2), and in the astrocyte/microglia (B-M5) module. GWAS risk candidate genes for both ASD (darkgreen) and schizophrenia (magenta) were significantly over-represented in the B-M1 and B-M4 neuron/synaptic modules (B) AD GWAS candidate genes in the transcriptome were overrepresented microglial/endothelial modules T-M3 and T-M18 and an oligodendrocyte associated module (T-M13). Similar to the proteome, ASD and schizophrenia GWAS targets were significantly over-represented in neuronal transcriptome modules (T-M1 and T-M9). ASD was also found in the oligodendrocyte enriched T-M13 module. Random sampling (10,000 times) of the MAGMA gene list was used to assess the significance of the module enrichment score (* p value <0.05).