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. 2017 Feb;139(2):607–620.e15. doi: 10.1016/j.jaci.2016.03.059

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig 1 — PHTS patient cohort and clinical phenotype. A, Representation of different pathogenic germline PTEN mutations in 79 patients with PHTS investigated. Symbols represent the mutation site of individual patients. Colored symbols represent patients who present with autoimmunity, lymphoid hyperplasia, or both. B, Immunologic conditions in the PHTS patient cohort. C, Peripheral blood leukocyte counts of adult patients with PHTS (n = 32) and blood donor control subjects (n = 216). Each dot represents 1 patient. Gray boxes mark the normal range. Statistical differences were analyzed by using the Mann-Whitney test. D, Numbers of CD19⁺, CD5⁺, CD10⁺ immature, and IgM^highCD38^high transitional B cells. E, Numbers of CD3⁺ T cells, percentages of CD4⁺ and CD8⁺ T cells among CD3⁺ T cells, and CD4⁺/CD8⁺ T-cell ratio.