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. 2017 Feb;139(2):607–620.e15. doi: 10.1016/j.jaci.2016.03.059

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig 3 — Phenotype of Treg cells in patients with PHTS. A, CD3⁺CD4⁺FOXP3⁺CD25⁺CD127⁻ cells (Treg cells) were compared with FOXP3⁻CD25⁻CD127⁺ (naive and central Tmem cells) and FOXP3⁻CD25⁻CD127⁻ cells (effector T cells). B, Expression levels of Helios are shown as a histogram and quantified in Treg cells. C, Expression levels of CTLA-4 are shown as a histogram and quantified in Treg cells. D, CD3⁺CD4⁺FOXP3⁺CD127⁻ (Treg) cells were compared with FOXP3⁻CD127⁺ (naive and central Tmem) and FOXP3⁻CD127⁻ (effector T cells) cells. CD25 expression in CD4⁺FOXP3⁺ Treg cells is shown as a histogram and quantified in Treg cells. No statistical differences were detected by using the Mann-Whitney U test.