Fig. 3.
G-SB2KO mice have multiple neurologic defects. (A) Examples of nests, scored on a scale from 1 to 4, showing a nest scoring 4 (Left) and 2 (Right). (B) Distribution of nesting scores, n = 12 control, 17 G-SB2KO, P < 0.05 by Wilcoxon Rank Sum. Eleven control and 12 G-SB2KO mice were trained in a Stone T-maze. (C) Four of the 12 G-SB2KO mice could not be trained to complete the maze. All 11 controls were trainable. P < 0.05 by two-proportion test. (D) One week after completing maze training, mice were retested and the average of three runs is shown. n = 11 control, 8 G-SB2KO. Mice were trained to cross a 12-mm-wide balance beam, then recorded crossing the balance beam two times and the average (E) time to cross and number of foot slips were reported. n = 8 control, 5 G-SB2KO, 9-wk-old females. Student’s t test *P < 0.05, **P < 0.01.