Fig. 4.
G-SB2KO mice have altered body composition and metabolism. (A) Ten-month-old females were dissected and tissue weights reported. n = 6 per group. (B) H&E staining of fat pads and livers from 3- to 4-mo-old males. (Scale bar, 200 μm.) BAT, brown adipose tissue; EDL, extensor digitorum longus; TA, tibialis anterior; WAT, white adipose tissue. Four-month-old female mice on chow diet were placed in metabolic cages for 72 h and (C) activity counts (beam breaks per 15-min interval, averaged over the light or dark cycle), (D) VO2, and (E and F) RER were determined. n = 6 per group. Student’s t test *P < 0.05, **P < 0.01, ***P < 0.001.