Table 2.
Top differentially abundant serum metabolites identified for BE versus GERD (A) or HGD/EA versus BE (B).
A. | ||||||
---|---|---|---|---|---|---|
Metabolite | N | Pa | qb | Covc | FCd,# | |
1 | Creatine | 162 | 0.0035 | 0.11 | 2 | 1.29 |
2 | Homocysteine | 162 | 0.0039 | 0.11 | 1.10 | |
3 | 3-Nitrotyrosine | 162 | 0.010 | 0.15 | 1.10 | |
4 | Hydroxyproline/Aminolevulinate | 162 | 0.011 | 0.15 | 1.16 | |
5 | Arginine | 162 | 0.018 | 0.20 | 1.07 | |
6 | Tyrosine | 162 | 0.026 | 0.24 | 1.10 | |
7 | Sorbitol | 162 | 0.033 | 0.26 | 1.09 | |
8 | Linoleic Acid | 162 | 0.037 | 0.26 | 1.13 | |
9 | Ornithine | 162 | 0.046 | 0.29 | 1.10 | |
| ||||||
10 | Urate | 162 | 0.119 | 0.62 | 2 | 1.05 |
B. | ||||||
---|---|---|---|---|---|---|
Metabolite | N | Pa | qb | Covc | FCd,# | |
1 | Urate | 160 | 0.0002 | 0.01 | 1.11 | |
2 | Taurine | 160 | 0.016 | 0.31 | 5 | 0.90 |
3 | Erythrose | 160 | 0.019 | 0.31 | 0.90 | |
4 | Xanthurenate | 160 | 0.021 | 0.31 | 2 | 0.94 |
| ||||||
5 | Aminoisobutyrate | 160 | 0.054 | 0.61 | 1 | 1.04 |
6 | Sorbitol | 160 | 0.116 | 0.81 | 1.06 | |
7 | Valine | 160 | 0.129 | 0.81 | 2 | 0.94 |
8 | Tryptophan | 160 | 0.149 | 0.81 | 2 | 0.95 |
9 | Methionine | 160 | 0.154 | 0.81 | 2 | 0.95 |
10 | Homocysteine | 160 | 0.169 | 0.81 | 1.05 |
P values were derived from linear regression of metabolite values on case status, with adjustment for indicated covariates[c],
False discovery rate (Benjamini and Hochberg),
Covariates included in linear regression model: age (1), sex (2), smoking (3), WHR (4), specimen storage duration (5),
Fold change of geometric mean signal,
Based on covariate-adjusted metabolite values. Metabolites above the horizontal lines reached nominal significance (P<0.05).