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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Metabolomics. 2017 Jan 20;13(3):23. doi: 10.1007/s11306-016-1154-y

Table 2.

Top differentially abundant serum metabolites identified for BE versus GERD (A) or HGD/EA versus BE (B).

A.
Metabolite N Pa qb Covc FCd,#
1 Creatine 162 0.0035 0.11 2 1.29
2 Homocysteine 162 0.0039 0.11 1.10
3 3-Nitrotyrosine 162 0.010 0.15 1.10
4 Hydroxyproline/Aminolevulinate 162 0.011 0.15 1.16
5 Arginine 162 0.018 0.20 1.07
6 Tyrosine 162 0.026 0.24 1.10
7 Sorbitol 162 0.033 0.26 1.09
8 Linoleic Acid 162 0.037 0.26 1.13
9 Ornithine 162 0.046 0.29 1.10
10 Urate 162 0.119 0.62 2 1.05
B.
Metabolite N Pa qb Covc FCd,#
1 Urate 160 0.0002 0.01 1.11
2 Taurine 160 0.016 0.31 5 0.90
3 Erythrose 160 0.019 0.31 0.90
4 Xanthurenate 160 0.021 0.31 2 0.94
5 Aminoisobutyrate 160 0.054 0.61 1 1.04
6 Sorbitol 160 0.116 0.81 1.06
7 Valine 160 0.129 0.81 2 0.94
8 Tryptophan 160 0.149 0.81 2 0.95
9 Methionine 160 0.154 0.81 2 0.95
10 Homocysteine 160 0.169 0.81 1.05
a

P values were derived from linear regression of metabolite values on case status, with adjustment for indicated covariates[c],

b

False discovery rate (Benjamini and Hochberg),

c

Covariates included in linear regression model: age (1), sex (2), smoking (3), WHR (4), specimen storage duration (5),

d

Fold change of geometric mean signal,

#

Based on covariate-adjusted metabolite values. Metabolites above the horizontal lines reached nominal significance (P<0.05).