Table 1.
Subject characteristics
| a. All (n = 2462) | b. SCD (n = 448) | c. MCI (n = 490) | d. AD-type dementia (n = 1031) | e. Non-AD-type dementia (n = 493) | |
|---|---|---|---|---|---|
| Age, years | 66.8 (7.0) | 64.4 (6.2)b,c,d | 68.2 (6.9)a,c,d | 67.3 (7.2)a,b | 66.9 (6.8)a,b |
| Female sex, n (%) | 1049 (43) | 170 (38)c | 181 (37)c | 528 (51)a,b,d | 170 (34)c |
| Years of education | 11.1 (3.0) | 11.9 (3.1)b,c,d | 11.4 (3.2)a,c,d | 10.8 (2.8)a,b | 10.5 (2.9)a,b |
| MMSE score | 23.6 (5.2) | 28.3 (1.7)b,c,d | 26.5 (2.5)a,c,d | 20.4 (5.0)a,b,d | 23.0 (5.2)a,b,c, |
| APOE ε4 allele carriers, n (%) | 1186 (54) | 158 (35)b,c | 242 (49)a,c,d | 615 (60)a,b,d | 171 (35)b,c |
| CSF Aβ1–42, pg/ml | 667 (289) | 906 (277)b,c,d | 676 (295)a,c,d | 504 (174)a,b,d | 781 (278)a,b,c |
| CSF tau, pg/ml | 527 (401) | 317 (205)b,c,d | 486 (313)a,c,d | 705 (406)a,b,d | 394 (443)a,b,c |
| CSF p-tau, pg/ml | 70 (37) | 52 (25)b,c | 70 (35)a,c,d | 88 (39)a,b,d | 50 (25)b,c |
| Outcome at follow-up AD-type/no AD-type dementia (% AD-type dementia) | – | 13/235 (5) | 146/224 (61) | – | – |
| Average follow-up duration, years | – | 2.93 (1.99) | 2.41 (1.46) | – | – |
Data are mean (SD), unless otherwise specified. Superscript letters indicate that this group shows a statistically significant difference (p < .05) with other groups as labelled with a,b,c,d or e in the column headers
Abbreviations: SCD Subjective cognitive decline, MCI Mild cognitive impairment, AD Alzheimer’s Disease, APOE Apolipoprotein E, CSF Cerebrospinal fluid, Aβ 1–42 β-Amyloid 1–42, - Not applicable