Table 3.
Genes displaying altered expression in MeCP2-deficient systems that encode oxidative defense factors.
| Gene | Coding genome | Protein function | Δ | Cell/ tissue type | Organism | References |
|---|---|---|---|---|---|---|
| SOD1 | nDNA | ROS scavenging enzyme | ↑ | Hippocampus | MeCP2-null mice | Großer et al., 2012 |
| Lympho-monocytes | Human (RTT patients) | Pecorelli et al., 2013 | ||||
| CAT | nDNA | Catalase | ↑ | Lympho-monocytes | Human (RTT patients) | Pecorelli et al., 2013 |
| PRDX1 | nDNA | Peroxiredoxin | ↑ | |||
| GSTO1 | nDNA | Glutathione S-transferase omega 1 | ↑ | |||
| MGST2, MGST3 | nDNA | Microsomal glutathione S-transferase | ↑ | |||
| Prdh | nDNA | Proline dehydrogenase | ↑ | Brain tissue | MeCP2-null mice | Urdinguio et al., 2008 |
| Ucp3 | nDNA | Uncoupling protein 3 | ↓ | Skeletal muscles | MeCP2-null mice | Gold et al., 2014 |