Fig. 1.
APP/PS1 mice are more susceptible to high-fat diet (HFD)–induced glucose intolerance, which is exacerbated with age. Experimental scheme for the two cohorts of (A) young (5 months) and (B) old (11 months) mice. Glucose tolerance test for young mice fed a standard chow (C) and a HFD (D) and old mice fed a standard chow (E) and a HFD (F). Insulin tolerance test for young mice fed a standard chow (G) and a HFD (H) and old mice fed a standard chow (I) and a HFD (J). Fasting blood glucose concentration for young mice fed a standard chow (K) and during high-fat feeding (L) and old mice fed a standard chow (M) and during high-fat feeding (N). Fasting insulin concentration for young mice fed a standard chow (O) and during high-fat feeding (P) and old mice during high-fat feeding (Q). Displayed are averages ± SEM. Statistical significance is defined as *P < .05, **P < .01. Wt n = 5 and APP/PS1 n = 4.