Table 1.
Studies linking Autoimmunity and ASD
| Type of Study | Research Group | Year | Findings |
|---|---|---|---|
| Case Study | Money et al. (35) | 1971 | Child with ASD had a family history of autoimmune disease |
| Research Study | Warren et al. (9) Mostafa et al. (14) |
1991 2010 |
The null allele of the C4B gene and the extended haplotypeB44-C30-DR4 is associated with autism. |
| Research Study | Warren et al. (10) | 1996 | The third hypervariable region (HVR-3) of certain DRP 1 alleles have very strong association with ASD. |
| Research Study | Torres et al. (11) | 2006 | The frequency of HLA-A2 alleles was significantly increased in autistic subjects compared with normal allelic frequencies |
| Research Study | Campbell et al. (12) |
2008 | The MET promoter variant rs1858830 C allele was associated with ASD |
| Population Study | Atladottir et al. (18) |
2009 | Increased risk of ASD in mothers with Rheumatoid Arthritis and Celiac Disease and in families with Type I Diabetes |
|
Systemic Review and Meta Analysis |
Wu et al. (20) | 2015 | A statistically significant association with ASD was observed in families with hypothyroidism, type I diabetes, rheumatoid arthritis and psoriasis |
|
Systemic Review and Meta Analysis |
Chen et al. (21) | 2016 | Children born to mothers with autoimmune disease were 34% more likely to develop ASD |