Table 2.
Studies linking Autoimmunity and ASD
| Antibody Target | MW | Number in Study |
Autoantibody Prevalence in ASD Population |
Research Group |
Year |
|---|---|---|---|---|---|
| Fetal Rat Brain | Low MW bands and 250kDa |
AU=11 TD=10 |
45%-Low MW bands 55%–250kDa |
Zimmerman et al. (51) |
2007 |
|
Fetal Human Brain |
37 and 73 kDa | AU=61 DD=40 TD=62 |
12% | Braunschweig et al. (50) |
2008 |
|
Fetal Human Brain |
39 kDa | AU=84 DD=49 TD=160 |
7% | Croen et al. (53) | 2008 |
|
Fetal Human Brain |
36kDa | AU=100 TD=100 |
10% | Singer et al. (52) | 2008 |
|
Fetal Monkey Brain |
37, 39, and 73 kDa | AU=201 ASD=71 DD=102 TD=185 |
7% (37 & 73 kDa) 4% (39 & 73 kDa) |
Braunschweig et al. (69) |
2012 |
|
LDH, STIP1, CRMP1, GDA, CRMP2, YBX1 |
37, 39, 48, 62 and 68 kDa |
ASD=246 TD=149 |
7% | Braunschweig et al. (64) |
2013 |
| Mouse Brain | Undetermined | ASD=2431 TD=653 |
10.7% | Brimberg et al. (55) |
2013 |
Abbreviations: Autism (AU), Typically Developing (TD), Developmental Delay (DD), and Autism Spectrum Disorders (ASD)