Table 2. EC50 determined by intravital microscopy in the cremaster muscle.
| WT
|
Cav-1 TG
|
|||
|---|---|---|---|---|
| Mean | SEM | Mean | SEM | |
| Phenylephrine | 1.50 × 10-6 | 6.20 × 10-7 | 2.97 × 10-6 | 1.20 × 10-6 |
| Acetylcholine | 7.40 × 10-6 | 3.34 × 10-6 | 5.67 × 10-6 | 2.14 × 10-6 |
| Bradykinin | 4.69 × 10-7 | 2.01 × 10-7 | 7.14 × 10-7 | 3.70 × 10-7 |
| Isoproterenol | 3.82 × 10-9 | 5.53 × 10-10 | 1.21 × 10-9 | 3.05 × 10-10 |
Potency of vasoconstrictors (phenylephrine) and vasodilators (acetylcholine, bradykinin, and isoproterenol) in the microcirculation of WT littermates and Cav-1 TG mice. Data are mean ± SEM, with n = 7 per group.