Table 2.

For each V1R gene cluster, the positions (format: chromosome number_Mb position) and orientation (arrowheads) of non-V1R genes near cluster boundaries in each genome are given. All genes shown are annotated human (in capital letters) or mouse (not fully capitalized) genes. The number of intact V1Rs (number of pseudogenes plus partial sequences in brackets) from identifiable subfamilies (A-P) in each cluster is shown for each species. In cases where orthologous non-V1R genes have not remained linked, the number of V1Rs located in clusters <1 Mb from one of the non-V1R genes (bold) is shown. Clusters (shaded) are defined as a group of at least three V1Rs with <500 kb between neighboring genes (exceptions are footnoted).

The numbers shown for the rat D cluster include an isolated intact D-like V1R located ~800 kb downstream of the main D cluster; the numbers shown for the rat ELG cluster include a pair of isolated pseudogenes (one E-like and one L-like) located ~800 kb upstream of the main cluster. The totals shown at the bottom of the table count these three V1Rs within the “Mapped Unclustered” category, according to our formal cluster definition.

The EF locus contains three linked clusters in rat and two linked clusters in chimpanzee and human; the V1R totals shown reflect all three rat and both primate clusters.

Zfp51 has ambiguous orthology. A more distant, less ambiguous flanking gene (PRPF31) is downstream of the nonrodent clusters; there is a syntenic break between Zfp51 and PRPF31 in mouse.

An inversion has split the rat “ELG” cluster into three clusters on rat Chromosome 1 (two EL clusters and one LG cluster; see Supplemental Material B). The numbers shown are totals in all three rat clusters. Note that owing to these rearrangements, the rat PRPF31 and Peg3 genes no longer flank the rat EF and ELG clusters, respectively (see Supplemental Material B).

The numbers shown for the chimpanzee EF and LP4 clusters each include a pair of isolated pseudogenes located ~800 kb away from the main clusters. The totals shown at the bottom of the table count these four V1Rs within the “Mapped Unclustered” category, according to our formal cluster definition.

The numbers shown for the human EF, LP2 and LP3 clusters includes two pseudogenes (L-like), three pseudogenes (two P-like and one L-like) and one pseudogene (L-like), respectively, that are located >500 kb away from the main clusters. The totals shown at the bottom of the table count these six V1Rs within the “Mapped Unclustered” category, according to our formal cluster definition.

The rat H-like pseudogene is located as a singleton on rat Chromosome 15.

The mouse ELG and JK loci are <500 kb apart (constitute one cluster by our definition).

Two intact dog J-like genes are unmapped.

An isolated, intact AB-like V1R is located at the 182.9 position (~3 Mb away from the CGI-49 gene) on mouse chromosome 1.

The LP2, LP3, LP4, and LP5 clusters are located in gene-poor pericentromeric regions.

This locus encompasses three clusters in chimpanzee.

This locus encompasses two clusters in chimpanzee.