Fig 4. Dysregulated ratios of one-hit and two-hit enzymes.
(a). single enzyme defect, (b). DAT and VMAT2 defects, (c). MAO and VMAT2 defects, (d). DAT and MAO defects. The enzyme activities of MAO and DAT decrease and the enzyme activity of VMAT2 increases. The combinations of two-enzyme dysregulation from the pairs of MAO, DAT, and VMAT2 cause an overexpression of various dopamine levels, namely 600, 700, 800, 900, 1000, 1100, and 1200. FC denotes the fold change between the disease state and the health state.