Skip to main content
. Author manuscript; available in PMC: 2017 Jun 19.
Published in final edited form as: Circ Res. 2011 Aug 11;109(7):739–749. doi: 10.1161/CIRCRESAHA.111.245530

Figure 8. Prdx2 deficiency shows severe predisposition to develop atherosclerosis than deficiency of GPx1 or catalase.

Figure 8

A and B, ApoE−/−, Prdx2−/− ApoE−/−, GPx1−/− ApoE−/−, and Cat−/− ApoE−/− male mice were fed an atherogenic cholate-containing diet for 10 weeks. A, Representative en face images showing oil red O-stained plaque areas of aortas. B, Percentage of plaque areas (mean±SD; n = 7 to 11). *P<0.05. C, Prdx2 deficiency increases VCAM-1 and ICAM-1 expression compared with deficiency of GPx1 or catalase in the arterial wall. En face immunofluorescence staining of VCAM-1 and ICAM-1 expression in the LC region of aortas from C57BL/6, Prdx2−/−, GPx1−/−, and Cat−/− mice (n=3) fed an atherogenic cholate-containing diet for 2 weeks.