. Author manuscript; available in PMC: 2018 Jan 1.

Published in final edited form as: Expert Opin Drug Discov. 2016 Nov 7;12(1):89–103. doi: 10.1080/17460441.2017.1253676

Table 3.

BBB Models based immortalized endothelial cell lines

Origin	Cell	Model Type	Approx TEER (ohm.cm²)	Ref
Mouse	bEnd.3	Monocuture	60–70	[132]
	bEnd.5	Monoculture	40–50	[133]
	Immortalized mouse cerebral endothelial cells (cEND)	Monoculture	400	[134]
Rat	RBE4	Monoculture	>100	[135]
Rat	RBE4	Coculture with rat glial cells	-	[136]
Human	Immortalized human brain endothelial cells (hCMEC/D3)	Monoculture	40–50	[24] [137]
		Coculture with astrocytes or pericytes	50–60	[24]
		Triculture with astrocytes & pericytes	>40	[24]