Figure 1.
PrPSc-inhibiting effects of phenothiazine derivatives and other psychopharmacological substances. Anti-PrP immunoblots of protease-digested ScN2a cell lysates treated with the respective substance for 6 days at the concentration indicated. Molecular mass markers at the right of the immunoblot correspond to 37 kDa (upper bands) and 20 kDa (lower bands). The characteristic PrP immunostain depicted corresponds to the amount of PrPSc and prion infectivity present in the neuroblastoma cells after treatment with the concentration indicated above. The schematic molecular structure of the compound used is depicted on the left side of each immunoblot.