Table 1.
CSF TNF, CRP, IL-8, IL-6, α-synuclein, and Aβ levels were disrupted in PD versus HC
| Quadratic effect | HC | PD | ||
|---|---|---|---|---|
| Serum analyte | F statistics | p value | F statistics | p value |
| TNF | F (1,5) = 0.06 | 0.82 | F (1,11) = 0.02 | 0.89 |
| IFNγ | F (1,5) = 0.48 | 0.52 | F (1,11) = 1.16 | 0.31 |
| NGAL | F (1,5) = 2.24 | 0.19 | F (1,11) = 1.37 | 0.27 |
| CRP | F (1,5) = 0.09 | 0.78 | F (1,11) = 3.62 | 0.08 |
| IL-6 | F (1,5) = 5.37 | 0.07 | F (1,11) = 0.10 | 0.76 |
| IL-8 | F (1,5) = 0.11 | 0.76 | F (1,11) = 2.88 | 0.12 |
| CSF Analyte | F statistics | p value | F statistics | p value |
| TNF | F (1,5) = 5.39 | 0.07 | F (1,10) = 7.47 | 0.02 |
| IFNγ | F (1,5) = 0.00 | 0.99 | F (1,10) = 1.24 | 0.29 |
| NGAL | F (1,5) = 0.16 | 0.71 | F (1,10) = 0.90 | 0.37 |
| CRP | F (1,5) = 1.67 | 0.25 | F (1,10) = 6.51 | 0.03 |
| IL-6 | F (1,5) = 15.00 | 0.01 | F (1,10) = 2.97 | 0.12 |
| IL-8 | F (1,5) = 1.28 | 0.31 | F (1,10) = 8.45 | 0.02 |
| α-synuclein | F (1,5) = 3.89 | 0.11 | F (1,11) = 6.02 | 0.03 |
| Aβ40 | F (1,5) = 26.36 | 0.004 | F (1,11) = 8.19 | 0.02 |
| Aβ42 | F (1,5) = 5.60 | 0.06 | F (1,11) = 11.60 | 0.006 |
An analysis of linear and quadratic trends indicated that levels of CSF inflammation rise and fall across the day in PD subjects more than HC. TNF, CRP, IL-8, α-synuclein, and Aβ42 levels in the CSF were best fit with a parabolic (not straight) line in PD, but not HC subjects. CSF IL-6 levels were best fit with a parabolic line in HC, but not PD