Table 3.
Reclassification of SWEDD patients according to the results of PD Net.
| SWEDD patients | Baseline SPECT (n = 77) |
2-years follow-up SPECT (n = 42) |
Clinical follow-up diagnosis (n = 56) | ||||
|---|---|---|---|---|---|---|---|
| n | Putamen BR | Caudate BR | PPMI visual consensus (abnormal:normal) | Putamen BR | Caudate BR | ||
| PPMI visual consensus normal/PD Net abnormal | 6 | 1.22 ± 0.24 | 1.33 ± 0.27 | 4:1 (80.0%)a | 1.01 ± 0.21 | 1.12 ± 0.15 | 4: PD 1: Alzheimer's dementia |
| PPMI visual consensus normal/PD Net normal | 71 | 2.03 ± 0.40 | 1.86 ± 0.40 | 2:35 (5.4%)b | 1.77 ± 0.45 | 1.64 ± 0.41 | 12: PDc 10: Essential tremor 10: No neurologic disease 6: Psychogenic illness 13: Other types of nonparkinsonian tremor |
| p-Value | 0.0002 | 0.002 | 0.0001 | 0.001 | 0.002 | ||
a
No follow-up imaging and clinical diagnosis data for a subject.
b
No follow-up imaging data for 34 subjects and no follow-up clinical diagnosis data for 20 subjects.
c
Among 12 subjects, two showed abnormal follow-up SPECT and 7 subjects showed normal follow-up scan, still clinically SWEDD. The others did not undergo 2-years follow-up SPECT.