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. Author manuscript; available in PMC: 2017 Sep 23.
Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 38.

Examples of novel oxalamido derivatives as caspase-3 inhibitors.375

No. graphic file with name nihms905431t204.jpg Enzyme assays IC50, μM
R R′ Casp-3
450 4-OCH3 fluoro 20.14
451 4-CH3 fluoro 9.67
452 4-F fluoro 3.47
453 4-OCH3 2,3,5,6-tetrafluorophenoxy >50
454 4-CH3 2,3,5,6-tetrafluorophenoxy 12.26
455 4-F 2,3,5,6-tetrafluorophenoxy >50
456 4-Br 2,3,5,6-tetrafluorophenoxy >50
457 4-Cl 2,3,5,6-tetrafluorophenoxy >50
458 4-OCH3 2,6-difluorophenoxy >50
459 3-OCH3 2,6-difluorophenoxy >50
460 2-OCH3 2,6-difluorophenoxy 8.4
461 4-CH3 2,6-difluorophenoxy >50
462 3-CH3 2,6-difluorophenoxy 25.2
463 2-CH3 2,6-difluorophenoxy >50
464 4-F 2,6-difluorophenoxy 14.2
465 2-F 2,6-difluorophenoxy >50