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. Author manuscript; available in PMC: 2017 Sep 23.
Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 40.

Ki(app) (or kobs/[I]) value calculated for AWP28 toward caspases and granzyme B.394

AWP28 476
Enzyme Ki(app), M−1sec−1 Fraction Caspase-1 activity
Caspase 1 16 764 000 ± 882 000 1.000
Caspase 3 1 505 000 ± 445 000 0.09
Caspase 4 7000 ± 1000 3.89 × 104
Caspase 6 2000 ± 1000 1.11 × 104
Caspase 7 1 412 000 ± 321 000 0.08
Caspase 8 594 000 ± 184 000 0.04
Granzyme B <1000 -