Table 6. . Table of candidate blood transcriptional markers possibly associated with Parkinson's disease.
| Transcript | Cohorts/country | Total n† | Direction‡ | Study (year) | Ref. |
|---|---|---|---|---|---|
|
SNCA (including long 3′UTR-SNCA)
|
HBS PPMI PROBE Portugal Sweden§ USA |
405 340 120 67 154 105¶ |
Reduced in early-stage and de novo PD Reduced in de novo PD Reduced in PD Reduced in fast progressing PD vs slow progressing PD Associated with PD Reduced in PD¶ |
Locascio et al. (2015) Locascio et al. (2015) Locascio et al. (2015) Pinho et al. (2016) Karlsson et al. (2013) Shehadeh et al. (2010) |
[92] [92] [92] [93] [94] [95] |
|
COPZ1 |
PROBE HBS PPMI |
124 96 200 |
Increased in PD Increased in PD Increased in de novo PD |
Potashkin et al. (2012) Santiago et al. (2013) Santiago & Potaskin, (2015) |
[96] [97] [98] |
|
ALDH1A1 |
Germany EU Italy |
153 185 24 |
Associated with PD§ Reduced in PD Reduced in de novo PD |
Grunblatt et al. (2010) Molochnikov et al. (2012) Calligaris et al. (2015) |
[99] [100] [101] |
|
LRPPRC |
USA Sweden |
48 154 |
Reduced in early and de novo PD Associated with PD§ |
Scherzer et al. (2007) Karlsson et al. (2013) |
[102] [94] |
|
BCL2 |
USA USA Sweden |
48 28 154 |
Reduced in early and de novo PD Reduced in PD Associated with PD§ |
Scherzer et al. (2007) Shehadeh et al. (2010) Karlsson et al. (2013) |
[102] [95] [94] |
|
BCL11B |
USA USA |
28 48 |
Reduced in early and de novo PD Reduced in PD |
Scherzer et al. (2007) Shehadeh et al. (2010) |
[102] [95] |
| APP | PROBE HBS |
95 96 |
Increased in PD Increased in PD |
Santiago et al. (2013) Santiago et al. (2013) |
[97] [97] |
†Total n includes number of patients with PD and controls assayed.
‡Direction for transcripts significantly differentially expressed; study-specific significance criteria were used.
§Direction of change not mentioned.
¶Select candidate transcripts, who met study-specific significance criteria with same directional change in at least two cohorts, were prioritized by the authors for inclusion in this table. This list is incomplete due to space limitations; it does not presume to represent the entire literature.
This is a reanalysis of the Scherzer, PNAS (2007) [102] microarray dataset performed by Shehadeh, PLoS ONE (2010) [95].
D: Parkinson's disease.